Sunday 21 December, 2014

Cells control energy metabolism via hedgehog signalling pathway

The binding of Sonig Hedgehog (Shh) to its receptor Patched (Ptch) causes the activation of Smo. In the previously known canonical pathways Smo in turn regulates gene expression via Gli transcription factors. In the newly discovered pathway, the activation triggers the influx of calcium and leads to the activation of various calcium-dependent enzymes, such as the calmodulin kinase (Camkk2), AMP-activated kinase (Ampk) and liver kinase B1 (Lkb1). This signalling pathway can also be specifically activated by agents such as cylcopamine. Both signal pathways change the metabolisms of muscle and brown fat cells, enabling them to rapidly absorb and utilise large quantities of glucose.
© Art For Science, Image courtesy: Max-Planck-Gesellschaft

Scientists discover novel diabetes and obesity therapy, and potential Continue reading “Cells control energy metabolism via hedgehog signalling pathway” »  More...

by BioNews | Published 2 years ago
Researchers at ASU and UA have discovered that regenerated lizard tails are quite different from original tails. Pictured here: Green anole male with a regenerated tail (brown region).
By BioNews On Tuesday, October 9th, 2012
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Researchers Discover Regenerated Lizard Tails Are Different From Originals

Just because a lizard can grow back its tail, doesn’t mean it will be exactly the same Continue reading “Researchers Discover Regenerated Lizard Tails Are Different From Originals” »  More...

Scientists Find Missing Link Between Players in the Epigenetic Code
By BioNews On Sunday, September 30th, 2012
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Scientists Find Missing Link Between Players in the Epigenetic Code

Over the last two decades, scientists have come to understand that the genetic code held within DNA Continue reading “Scientists Find Missing Link Between Players in the Epigenetic Code” »  More...

muscle_structure
By BioNews On Thursday, September 27th, 2012
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Scientists find way of reversing muscle waste in attempt to combat ageing

A key factor which slows down muscle repair during ageing can also be reversed Continue reading “Scientists find way of reversing muscle waste in attempt to combat ageing” »  More...

The hearts of the mice that possess more of the microRNAs 212 and 132 (on the right) are distinctly larger than the hearts of the normal mice (on the left). (Image: Kamal Chowdhury / Max Planck Institute for Biophysical Chemistry)
By BioNews On Tuesday, September 25th, 2012
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Scientists prevent heart failure in mice

Cardiac stress, for example a heart attack or high blood pressure, frequently leads to pathological Continue reading “Scientists prevent heart failure in mice” »  More...

By BioNews On Friday, July 20th, 2012
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Cells from human placenta could be useful in treating heart disease

Endothelial colony-forming cells (ECFCs) derived from human placenta are better for forming blood vessels than the ECFCs derived from umbilical cord blood, according to a new study Continue reading “Cells More...

By BioNews On Friday, July 6th, 2012
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How protein meal makes you feel full

Feeling full is not just limited to getting the uncomfortable sensation that your waistband is getting tight Continue reading “How protein meal makes you feel full” »  More...

By BioNews On Friday, July 6th, 2012
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Mechanism that controls both obesity and atherosclerosis identified

Scientists from the Institute of Molecular and Cell Biology (IMCB) and the Singapore Bioimaging Consortium (SBIC) have discovered a new signalling pathway that controls both obesity Continue reading “Mechanism More...

By BioNews On Sunday, June 24th, 2012
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Most commonly mutated gene in cancer `may play role in stroke`

Researchers have found that the gene p53, which is the most commonly mutated gene in cancer, has a novel role in the development of ischemic stroke Continue reading “Most commonly mutated gene in cancer `may More...

By BioNews On Friday, June 15th, 2012
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Milk compound keeps you slim despite lazy lifestyle

Traces of a cousin of vitamin B3, found in milk, produces startling health benefits such as keeping you slim inspite of a fatty diet and lazy lifestyle Continue reading “Milk compound keeps you slim despite More...