Fish compound can fight against heart disease
Sunday 19 November, 2017

Fish compound can fight against heart disease

Published On: Tue, Jan 13th, 2015 | Pharmaceutical Science | By BioNews

A peptide originally found in fish could be used in the battle against cardiovascular disease, research has found.

The peptide Urotensin II (UII) was first isolated from teleost fish, a class of ray-finned fishes.

UII can modulate a vast array of biologic activities encompassing the cardiovascular system, kidneys and central nervous system, the findings showed.

“We have been working on this exciting peptide for a number of years; it exhibits a very interesting pharmacological profile. Design and evaluation of small molecule drugs has potential for use in the treatment of several cardiovascular diseases,” said professor David Lambert from the University of Leicester in Britain.

Interestingly, the peptide can constrict some blood vessels yet dilate others, the researchers noted.

The study appeared in the journal Pharmacological Reviews.


Hubert Vaudry, Jérôme Leprince, David Chatenet, Alain Fournier, David G. Lambert, Jean-Claude Le Mével, Eliot H. Ohlstein, Adel Schwertani, Hervé Tostivint, and David Vaudry. International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, Urotensin II–Related Peptide, and Their Receptor: From Structure to Function. Pharmacol Rev January 2015 67:214-258; published online December 22, 2014, doi:10.1124/pr.114.009480

Leave a comment

XHTML: You can use these html tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

More from Pharmaceutical Science
  • Single drug soon to cure high cholesterol, breast cancer
  • Soon, take the pill through nasal spray
  • New drug to protect unvaccinated people from measles
  • France seizes 13 tonnes of fake Chinese pills
  • Indian researchers developed 16 disaster management drugs