Friday 31 October, 2014

Gene behind brain development discovered

Published On: Sun, Apr 6th, 2014 | Developmental Biology | By BioNews

In a breakthrough, scientists have found a gene key for the development of our brain.

The study shows how mutations in the gene called USP9X are linked to intellectual disability.

These mutations – inheritable from one generation to the next – are believed to cause disruptions to normal brain cell functioning.

By looking at patients with severe learning and memory problems, scientists discovered this particular gene that is involved in creating this base network of nerve cells.

“The USP9X gene has shed new light on the mysteries of brain development and disability,” said Lachlan Jolly from the University of Adelaide.

“Disorders that cause changes to this network of cells, such as intellectual disabilities, epilepsy and autism, are hard to understand, and treat,” he added.

USP9X controls both the initial generation of the nerve cells from stem cells, and also their ability to connect with one another and form the proper networks.

The findings would be crucial to understand how the brain develops and how it is altered in individuals with brain disorders.

By learning more about genes such as USP9X, scientists may create new opportunities to understand brain disorders at a much deeper level than currently known, he added.

The study was published in the American Journal of Human Genetics.

Reference:

Homan CC, Kumar R, Nguyen LS, Haan E, Raymond FL, Abidi F, Raynaud M, Schwartz CE, Wood SA, Gecz J, Jolly LA. Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth. Am J Hum Genet. 2014 Mar 6;94(3):470-8. doi: 10.1016/j.ajhg.2014.02.004.

Leave a comment

XHTML: You can use these html tags: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>

More from Developmental Biology
  • World’s number of IVF and ICSI babies reach 5 million mark
  • Rats exhibit human-like empathy to help ‘distressed’ fellow rodents
  • Diabetes drug could help cut risk of cancer
  • New ‘tumour-seeking’ drug brings new hope for cancer patients
  • Soon, wonder drug to make cancer cells ‘commit suicide’
  • Visit us on Google+