Tuesday 22 July, 2014

Aspirin may cut down colon cancer risks too

Published On: Thu, Apr 24th, 2014 | Cancer Research | By BioNews

The humble aspirin that you pop to ameliorate headache or a precaution against heart attack can also take on the dangerous colorectal cancer in people with a specific gene, a significant study shows.

“Individuals whose colons have high levels of a specific gene product – 15-hydroxyprostaglandin dehydrogenase (15-PGDH) RNA – dramatically reduce their chances of developing colorectal cancer by taking aspirin,” said the researchers.

Aspirin, however, provides no benefit to individuals whose colons show low levels of 15-PGDH, the researchers added.

“If you looked at the folks from the study who had high 15-PGDH levels and took aspirin, they cut their risk of colon cancer by half,” said Sanford Markowitz, a professor at Case Western Reserve School of Medicine in the US.

“If you looked at the folks from the study that were low for 15-PGDH, they did not benefit at all from taking aspirin,” Markowitz added.

The extraordinary finding comes from a multi-institutional team that analysed data and other material from two long-term studies involving nearly 128,000 participants.

The study appeared in the journal Science Translational Medicine.

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