Synthetic cannabinoid may treat brain cancerPublished On: Sun, Sep 30th, 2012 | Brain Cancer | By ANI
Researchers in a US cancer centre are evaluating the safety and tolerability of a synthetic cannabinoid called dexanabinol (ETS2101).
Delivered as a weekly intravenous infusion, the drug is being tested in patients with all forms of brain cancer, both primary and metastatic.
“In this Phase I study, we are examining the safety of multiple doses of dexanabinol, extent of penetration into the brain, and suitability for future trials,” Santosh Kesari, MD, PhD, principal investigator, and director of neuro-oncology, UC San Diego Moores Cancer Center, said.
Dexanabinol is a cannabinoid derivative that causes no psychotropic effects.
It was tested previously as a neuroprotective in patients with traumatic brain injury.
During these trials the drug was found to cross the blood-brain barrier.
More recently, researchers at e-Therapeutics plc, who are supporting the current trial, showed that dexanabinol kills cultured cancer cells derived from many tumor types.
Additional research in Kesari’s lab demonstrated the drug’s anti-cancer effects in patient-derived brain cancer cell lines.