Wednesday 22 October, 2014

Heavy snorers at ‘double risk’ of rheumatoid arthritis

Published On: Fri, Jun 29th, 2012 | Rheumatology | By BioNews

Heavy snoring almost doubles the risk of developing rheumatoid arthritis, a new study has revealed.

Researchers found that patients diagnosed with the snoring-related condition sleep apnoea were nearly twice as likely to suffer from the joint-damaging disease.

The discovery has turned out to be a surprise as rheumatoid arthritis – which affects around 350,000 people in the UK – is apparently triggered when something goes wrong with the immune system.

The study also found a similar increase in the risk of other so-called autoimmune disorders, where the body’s defences start to attack healthy tissues.

Scientists said that they believe the explanation lies in the fact that chronic sleep apnoea can lead to inflammation in blood vessels throughout the body, which may act as a catalyst for arthritis.

Previous studies have suggested sleep apnoea may raise the risk of heart attacks, but the latest investigation is the first to show a link with arthritis.

An estimated three million people in Britain suffer with sleep apnoea, though many more may remain undiagnosed.

As sleep begins, the muscles in the airway relax. For most people this does not pose a problem but in sleep apnoea, it leads to a complete collapse, which shuts off breathing for at least ten seconds.

It also disrupts breathing and triggers the sound of snoring as air vibrates against the soft tissue that stands in its way.

Once the brain realises breathing has stopped it sends out a signal for the airway muscles to contract again.

This opens the airway and the sufferer normally wakes with a jolt. In mild sleep apnoea, this can happen about once every ten minutes. If it’s severe, it means sleep can be disturbed every couple of minutes.

Very few people remember waking up at all because they fall asleep again within seconds.

Yet the cumulative effect is that they feel exhausted during the day, putting them at increased risk of accidents. Being overweight is one of the major risk factors.

In the latest study, by experts at the Taipei Medical University, 1,411 sleep apnoea patients were compared to a 7,000-strong group of healthy adults.

Over a five-year period, researchers monitored how many people in each group went on to develop rheumatoid arthritis, ankylosing spondylitis and systemic lupus erythematous – all conditions where the immune system goes haywire and cause swollen, painful joints and flu-like symptoms.

The results showed that the snoring-affected group were 91 percent more likely to develop one of the three conditions.

However, the researchers stressed that the absolute risk of falling ill was still small. Out of the snoring patients, only 2.91 percent experienced arthritis-related problems.

“But the potential link between these two conditions should not be overlooked. Among the diseases we studied, rheumatoid arthritis had the highest risk of developing in sleep apnoea patients,” the researchers said.

Apart from inflamed and swollen joints, arthritis sufferers also experience flu-like symptoms. In very severe cases, they can end up crippled and unable to lead a normal life.

The results were recently published in the journal Sleep Medicine.

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