Friday 18 April, 2014

How antibody disarms HIV virus by using its sugar cloak

Published On: Thu, Nov 24th, 2011 | Virology | By BioNews

A new study has shed light on how one broadly neutralizing HIV antibody actually uses part of the sugary cloak to help bind to the virus and disarm it.

HIV is coated in sugars that usually hide the virus from the immune system.

The study led by Peter D. Kwong, Ph.D., chief of the Structural Biology Section of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases (NIAID), said the antibody binding site, called the V1/V2 region, represents a suitable HIV vaccine target.

In addition, their research revealed the detailed structure of the V1/V2 region, the last part of the virus surface to be visualized at the atomic level.

Some people who have been infected with HIV for several years begin to make antibodies that can neutralize a wide range of virus strains.

These broadly neutralizing antibodies bind to one of four sites on the virus. One site involves a sugar at a spot called amino acid residue 160. (Amino acids are the building blocks of proteins.) The sugar is located on the protein-based spikes that jut out of the surface of HIV.

The new study demonstrated how a broadly neutralizing HIV antibody called PG9 disarms the virus by grabbing hold of the sugar at residue 160, along with part of a second sugar and a short string of amino acid residues in the V1/V2 region of an HIV spike.

Similarly, a separate, recently published report* from the IAVI Neutralizing Antibody Center at The Scripps Research Institute showed how a different broadly neutralizing HIV antibody also binds to the virus via two sugars and a string of amino acid residues.

Taken together, these two studies indicate that in some cases, the combination of viral sugars and amino acids can form the binding site for broadly neutralizing HIV antibodies.

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