Contraceptive pill use linked to high prostate cancer risk worldwidePublished On: Tue, Nov 15th, 2011 | Prostate Cancer | By BioNews
A news study has found that use of the contraceptive pill appears to increase risk of prostate cancer around the globe.
According to the researchers, prostate cancer is the most common male cancer in the developed world and the use of the contraceptive pill has soared over the past 40 years.
The research team used data from the International Agency for Research on Cancer (IARC) and the United Nations World Contraceptive Use report to pinpoint rates of prostate cancer and associated deaths and the proportion of women using common methods of contraception for 2007.
They then analysed the data for individual nations and continents worldwide to see if there was any link between use of the contraceptive pill and illness and death caused by prostate cancer.
Their calculations showed that use of intrauterine devices, condoms, or other vaginal barriers was not associated with an increased risk of prostate cancer.
But use of the contraceptive pill in the population as a whole was significantly associated with both the number of new cases of, and deaths from, prostate cancer in individual countries around the world, the analysis showed.
The researchers emphasise that their research is speculative and designed to prompt further consideration of the issues. As such, their analysis does not confirm cause and effect, and therefore definitive conclusions cannot be drawn, as yet.
But they refer to several recent studies, which have suggested that oestrogen exposure may boost the risk of prostate cancer.
Excess oestrogen exposure is known to cause cancer, and it is thought that widespread use of the Pill might raise environmental levels of endocrine disruptive compounds (EDCs) – which include by-products of oral contraceptive metabolism.
“Temporal increases in the incidence of certain cancers (breast, endometrial, thyroid, testis and prostate) in hormonally sensitive tissues in many parts of the industrialised world are often cited as evidence that widespread exposure of the general population to EDCs has had adverse impacts on human health,” the team concluded.
The finding has been published in BMJ Open.