Sunday 23 November, 2014

Cholesterol-lowering drug could protect kidneys after surgery

Published On: Tue, Apr 12th, 2011 | Kidney Diseases | By BioNews

A new study involving an Indian-origin researcher has suggested that taking a cholesterol-lowering drug called statin before having major elective surgery could potentially reduce serious kidney complications.

Each year, more than 230 million major elective surgeries are performed around the world. Unfortunately, many patients who undergo major operations develop kidney injury soon after surgery, often due to decreased blood flow to the kidneys and/or the effects of inflammation.

Animal studies suggest that statins protect the kidneys from such damage, but whether a similar benefit occurs in humans is uncertain.

To investigate, Amber Molnar, (University of Western Ontario and Lawson Health Research Institute, in London, Canada), Amit Garg, (University of Western Ontario and Lawson Health Research Institute, in London; and the Institute for Clinical Evaluative Sciences, in Toronto, Canada) and their colleagues conducted a population-based retrospective study of all older patients who underwent major elective surgery in the province of Ontario, Canada from 1995 to 2008. Surgeries included cardiac, thoracic, vascular, intra-abdominal, and retroperitoneal procedures.

A total of 213,347 patients from 211 hospitals underwent major elective surgery, and 4,020 patients (1.9 percent) developed postoperative kidney injury within two weeks of surgery. A total of 1,173 patients (0.5 percent) required dialysis within two weeks of surgery, and 5,974 patients (2.8 percent) died within a month of surgery.

Prior to surgery, 67,941 patients (32 percent) were taking a statin. Patients taking a statin were 20 percent less likely to develop kidney injury, need dialysis, and die compared to patients who were not taking a statin. Also, there was evidence of a dose-effect, with patients on higher potency statins having less kidney injury. In addition, statins were beneficial whether they were started greater than 90 days or less than 30 days prior to surgery.
The study appears in an upcoming issue of the Journal of the American Society Nephrology.

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