Sunday 21 December, 2014

Combination ACE inhibitor therapy raises risk of kidney failure, death

Published On: Tue, Mar 22nd, 2011 | Kidney Diseases | By BioNews

A new study has warned that elderly patients who have been prescribed combination angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) have a higher risk of kidney failure and death.

This study, by researchers from the University of Alberta and the University of Calgary, sought to determine the safety of combination therapy of ACE inhibitors and ARB in the clinical setting as some randomized trials indicate an increased risk of kidney failure.

The researchers looked at 32 312 seniors in Alberta, Canada, aged 65 and older who were prescribed an ACE inhibitor and/or an ARB. They compared patients receiving both drugs together with patients who received only one of the drugs. They found a higher risk of adverse events such as high creatinine levels, end-stage renal disease and death in people taking combination therapy.

“We found that less than one-seventh of the elderly residents of Alberta who were given combination therapy in clinical practice had either of the conditions for which this therapy has been proven beneficial in randomized trials (i.e., proteinuria or symptomatic left ventricular systolic dysfunction despite treatment with and ACE inhibitor or an angiotensin-receptor blocker alone,” said Dr. Finlay McAlister, University of Alberta, with co-authors.

As well, they observed that within three months, most patients stopped the combination therapy. The authors speculate this may have been due to low blood pressure.
The study is published in CMAJ (Canadian Medical Association Journal).

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