News Section | Microbiology
WHO endorses new test for detecting TB in less than 2 hours
Dr. David Alland, chief of the Division of Infectious Disease at UMDNJ-New Jersey Medical School, is the driving force behind the rapid
tuberculosis test that received World Health Organization endorsement this week.
The test, which uses DNA technology to diagnose tuberculosis in less than two hours, will be widely distributed to countries around the world.
WHO says the new test “represents new hope for the millions of people who are at the highest risk of TB and drug-resistant disease.”
The testing technology that it replaces, which is 125 years old, is far less reliable and requires three months to produce a diagnosis.
The quicker and more accurate diagnoses produced by Dr. Alland’s test will allow healthcare providers to begin tuberculosis treatment far sooner, sharply reducing the risk that infected individuals will spread the disease to others.
It also will lead to more effective treatment of individual patients by telling clinicians whether disease-causing bacteria are drug-resistant.
Dr. Alland began work on the screening test, which is called Xpert MTB/RIF (Mycobacterium tuberculosis/resistance to rifampin), more than a decade ago.
The test took four years to develop, followed by the process of attracting funding to refine and manufacture it and then conducting the clinical trials that established its effectiveness. (ANI)
Reference:
Rapid Molecular Detection of Tuberculosis and Rifampin Resistance
Catharina C. Boehme, M.D., Pamela Nabeta, M.D., Doris Hillemann, Ph.D., Mark P. Nicol, Ph.D., Shubhada Shenai, Ph.D., Fiorella Krapp, M.D., Jenny Allen, B.Tech., Rasim Tahirli, M.D., Robert Blakemore, B.S., Roxana Rustomjee, M.D., Ph.D., Ana Milovic, M.S., Martin Jones, Ph.D., Sean M. O’Brien, Ph.D.,David H. Persing, M.D., Ph.D., Sabine Ruesch-Gerdes, M.D., Eduardo Gotuzzo, M.D., Camilla Rodrigues, M.D.,David Alland, M.D., and Mark D. Perkins, M.D.
New England Journal of Medicine, 2010, Vol 363, No.11, doi:10.1056/NEJMoa0907847
This is great news since the current technology is already 125 years old and TB has existed for decades. Hopefully, this new DNA technology will prevent the spread of the disease worldwide.