News Section | Cell Biology
MultiCell Licensee Presents Immortalized Cell Lines at In Vitro Screens in Drug Metabolism Conference
MultiCell Technologies, Inc., leading supplier of functional non-tumorigenic immortalized human hepatocyte lines Fa2n-4 and EA1C-35, announced that XenoTech LLC, its marketing and manufacturing licensee, will present MultiCell’s cells at the In Vitro Screens conference to be presented by Cambridge Healthtech Institute on Dec. 13 and 14 in Lake Buena Vista, FL. The conference theme is Decision Gates for Early Drug Development. Dr. Andrew Parkinson of XenoTech will speak on “The use of Fa2N-4 Immortalized Human Hepatocytes for In Vitro Screening,” and will be featured in the section of the program called “Assay Development with Novel Approaches to Drug Metabolism.”
Predicting how a drug will behave in humans before clinical testing requires sophisticated in vitro tests to complement in vivo tests. Early drug metabolism models can help predict drug-drug interactions and help prioritize compound selection for further development.
Drug induced liver injury is now the leading cause of liver failure in the U.S. As drug recalls occur, and labor and animal costs rise, affordable early screening is demanded.
MultiCell’s immortalized human hepatocyte lines closely resemble primary human liver cells in morphology and function. Hepatocytes express drug-metabolizing enzymes that biotransform drugs or substances ingested into the body, so they help predict the effect of a compound on human livers. MultiCell’s cell lines are sensitive to compounds that increase the expression of CYP3A4, an essential feature of in vitro model systems when studying drug-drug interactions. They eliminate the problem of limited supply and organ donor variability that restrict the use of harvested human liver cells for enzyme induction, cellular toxicity assays and other in vitro screening. (BUSINESS WIRE)
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